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抑制剂 & 化合物

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化合物库

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重组蛋白

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Cat. No. Product Name
L7600 趋化因子抑制剂库

59 compounds
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选;

化合物库

趋化因子抑制剂库
Cat.No: L7600
Compounds: 59
Cat. No. Product Name Target Signaling Pathways
T35794 Kisspeptin-54 (human) (trifluoroacetate salt)

Kisspeptin-54 is a peptide ligand of the orphan G protein-coupled receptor GPR54 (Kis = 1.81 and 1.45 nM for rat and human receptors, respectively).1 It is a 54 amino acid peptide encoded by the metastasis suppressor gene KISS-1. Kisspeptin-54 induces calcium mobilization in CHO-K1 cells expressing rat and human receptors (EC50s = 1.39 and 5.47 nM, respectively). It also induces arachidonic acid release in CHO cells expressing rat and human GPR54 in a concentration-dependent manner. Kisspeptin-5...
T83697 PAMP-12 (human, mouse, rat, porcine, bovine) TFA

Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段,源自人体肾上腺髓质,对应人类PAMP-20的9-20氨基酸,涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中,PAMP-12抑制forskolin诱导的cAMP积累(EC50 = 57.2 nM),特异性诱导表达MRGPRX2的CHO细胞的钙离子动员(EC50 = 41 nM),而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应(在1 µM浓度下)。PAMP-12还能作为烟碱型乙酰胆碱受体(nAChRs)的拮抗剂,抑制carbachol诱导的儿茶酚胺释放(IC50 = 1.3 µM)及钙和钠的流入(IC50分别为0.39 µM和0.87 µM),但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入(IC50 >1 µM),在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时,PAMP-12能降低平均动脉血压。

化合物

Kisspeptin-54 (human) (trifluoroacetate salt)
Cat.No: T35794
Synonym:
Target:
PAMP-12 (human, mouse, rat, porcine, bovine) TFA
Cat.No: T83697
Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
Target:
Cat. No. Product Name Species Expression System
TMPH-02612 CXCR3 Protein, Mouse, Recombinant (His & KSI)

CXC-R3,CKR-L2,CXCR3,CD183,GPR9,Interferon-...

Mouse E. coli
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
TMPH-01162 CXCR3 Protein, Human, Recombinant (GST & His)

IP-10 receptor,CXCR3,CXC-R3,GPR9,...

Human E. coli
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
TMPJ-00884 CXCL9 Protein, Mouse, Recombinant (His)

Protein m119,C-X-C motif chemokine 9

Mouse HEK293 Cells
Chemokine (C-X-C motif) ligand 9 (CXCL9, MIG), is a small cytokine belonging to the CXC chemokine family. CXCL9 functions as one of the three ligands of chemokine receptor CXCR3 which is a G protein-coupled receptor found predominantly on T cells. It together with CXCL10 and CXCL11, may activate CXCR3 by binding to it. CXCL9 serves as a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. It has been observed that tumour e...
TMPJ-00865 VEGF121 Protein, Human, Recombinant (His)

VEGFA,VEGF-A,Vascular permeability factor,...

Human HEK293 Cells
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698 VEGF121b Protein, Human, Recombinant

MVCD1,VEGF,VPF,vascular endothelial growth...

Human HEK293 Cells
VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005 YAP1 Protein, Human, Recombinant (Isoform 9, His)

YAP1-2delta

Human P. pastoris (Yeast)
YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825 VEGF121 Protein, Human, Recombinant (His & Avi)

VPF,VEGF,VEGFA,VEGFMGC70...

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826 VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

VAS,VEGFMGC70609,RP1-261G

Human HEK293 Cells
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268 Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

NRCAML,neurofascin,NF

Human HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.
TMPK-01411 Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated

Peptide Ready,HLA-G,MHC

Human HEK293 Cells
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.
TMPK-01418 Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi)

MHC,HLA-G,Peptide Ready

Human HEK293 Cells
Peptide Ready HLA-G&B2M Monomer is absent from peptide, namely peptide-receptive MHC. It can be loaded with antigenic peptides matching HLA-G. Peptide ready MHC molecules comprising human HLA alleles and B2M, which can be readily tetramerized and loaded with peptides of choice in a high-throughput manner.

重组蛋白

CXCR3 Protein, Mouse, Recombinant (His & KSI)
Cat.No: TMPH-02612
Species: Mouse
Expression System: E. coli
CXCR3 Protein, Human, Recombinant (GST & His)
Cat.No: TMPH-01162
Species: Human
Expression System: E. coli
CXCL9 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00884
Species: Mouse
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His)
Cat.No: TMPJ-00865
Species: Human
Expression System: HEK293 Cells
VEGF121b Protein, Human, Recombinant
Cat.No: TMPY-03698
Species: Human
Expression System: HEK293 Cells
YAP1 Protein, Human, Recombinant (Isoform 9, His)
Cat.No: TMPH-00005
Species: Human
Expression System: P. pastoris (Yeast)
VEGF121 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-00825
Species: Human
Expression System: HEK293 Cells
VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-00826
Species: Human
Expression System: HEK293 Cells
Neurofascin Protein, Human, Recombinant (hFc), Biotinylated
Cat.No: TMPY-05268
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi), Biotinylated
Cat.No: TMPK-01411
Species: Human
Expression System: HEK293 Cells
Peptide Ready HLA-G&B2M Monomer Protein, Human, MHC (His & Avi)
Cat.No: TMPK-01418
Species: Human
Expression System: HEK293 Cells
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